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Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release

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2 , 9 Patients diagnosed with MMNST must be managed aggressively and early through an individualized approach that includes neurosurgical intervention for resection, applicable decompression, and biopsy, as well as adjuvant radiation therapy, depending on the extent of the tumor