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5 Regulatory mechanisms of glucose metabolic reprogramming 5.1 NRG1/ErbB signaling pathway and regulation of cardiac metabolic status At the regulatory level, in models of cardiac injury and regeneration, activation of NRG1/ErbB2 signaling has been shown to induce a metabolic shift in cardiomyocytes from fatty acid oxidation toward glycolysis, providing readily available energy and biosynthetic precursors to support cell proliferation and tissue repair

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