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License Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Content URL Doctor's Note This is the second video in an extended series on the critically important topic of how to lower LDL cholesterol, the primary driver of our primary killer

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It does not act through a single high-affinity receptor

Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA ( Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO ( This narrative review summarizes the current clinical evidence on GLP-1RAs in PsO and PsA and discusses future research directions aimed at evaluating their potential role in intercepting PsA development and improving outcomes in patients with complex immunometabolic profiles