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That design may improve stomach tolerability for some people, although it does not remove all gastrointestinal risk

20 Similar results were obtained in a phase III trial including saxagliptin 5 mg and 10 mg in combination with maximal doses of metformin compared to saxagliptin and metformin alone

While these ROS serve antimicrobial functions, excessive generation may cause oxidative damage to host cells, precipitating OS ( The intestinal barrier integrity is damaged by enhanced OS

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