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Both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) can affect bone mineral density (BMD) and the risk of bone fractures ( The Impact of GLP-1 on Bone Metabolism The Impact of GLP-1 on BMD Glucagon-like peptide-1 may enhance BMD

The present study aims to determine whether successful treatment with narrowband ultraviolet B (UVB) phototherapy combined with topical steroids affects changes in the microbiome of vitiligo patients

Primary outcome: Percentage change in body weight and the proportion of participants who lost at least 5% of baseline weight by week 68 Results: Primary outcome (% weight loss): Wegovy - 16%, Placebo - 5.7% (p 35 - 68.9% Randomized treatment groups Group 1 (374 patients): Tirzepatide titrated to the maximum tolerated dose of 10 mg or 15 mg once weekly Group 2 (376 patients): Semaglutide titrated to the maximum tolerated dose of 1.7 mg or 2.4 mg once weekly Tirzepatide was initiated at a dose of 2.5 mg once weekly, and the dose was increased by 2.5 mg every 4 weeks until a maximum tolerated dose of 10 mg or 15 mg was reached

These studies suggest that T

Future approaches may combine these strategies, for example, by knocking out the endogenous CUL5 gene in CUL5-targeting TCR-T cells