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Platelet activation was studied by dosing sCD40L

In patients with suspected cobalamin hypersensitivity, consider administering an intradermal test dose of parenteral vitamin B12 prior to use of NASCOBAL [see Warnings and Precautions (5.2)]

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The current combination of uncertain benefit and uncertain product integrity warrants a cautious and structured clinical approach

In the cells, this probe is converted into dichlorodihydrofluorescein (H2DCF) that in the presence of oxidant species is oxidized into fluorescent dichlorofluorescein (DCF)