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doi: 10.1016/j.trecan.2023.02.001 101 Calvillo-RodrguezKMLorenzo-AnotaHYRodrguez-PadillaCMartnez-TorresACScott-AlgaraD

xCT (Xc cystine/glutamate antiporter) is an important component of antioxidant activity in vivo , which is associated with glutathione synthesis (100)

~200 in mice) and lipid metabolism pathways (e.g., bile acid synthesis) are different, rendering animal study results non-translatable to humans (8890)

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In summary, the regulation of the AMPK and PPAR pathways via nanodelivery systems offers a promising therapeutic strategy for NAFLD, effectively improving liver steatosis, inflammation, and insulin resistance