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Our qPCR analysis shows that exposure to ADA potentiates the expression of the A1 receptor and forms multinucleated cells to with increased TRAP activity whereas treatment with heat-inactivated ADA and the ADA along with its inhibitor EHNA shows a decreased expression of the A1 receptor suggesting that ADA can enhance the osteoclastogenesis through the A1 receptor

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Jaiswal, A., Dewani, D., Reddy, L

This leads to local ischemia, hypoxia, reduced pH, and decreased temperature, all of which lower uric acid solubility and impair urate excretion