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Early initiation of folic acid supplementation (210 mg/kg/day) is recommended, and patients who begin supplementation before the age of 6 years tend to have a better prognosis than those who start supplementation after the age of 6 years [101]

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Additionally, it improves liver enzyme levels, reduces steatosis and stiffness, and thereby reduces the risk of liver fibrosis

GIP (142) Asp 21 may form a hydrogen bond with GIPR Arg 131 and the mutation of GIPR Arg 131 to Ala decreases the affinity and activity