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Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options. oral vitamin B12 is an effective alternative to vitamin B12 IM injections Cochrane Review

Studies have demonstrated its efficacy in models of insomnia and circadian rhythm disruption, with a normalization of the slow-wave/REM sleep ratio (Graf et al., Pharmacol Biochem Behav 1984)

Zinc also functions as a mild inhibitor of 5-alpha reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT), thereby helping to blunt the hormonal fluctuations that often trigger excessive sebum production

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