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The PIONEER 6 study included 3183 T2DM patients who had ASCVD or who were at high risk, of whom 1591 were treated with oral semaglutide and 1592 were treated with placebo for a median time of 15.9 months [40]

The compounded tirzepatide market faced its own disruption when the FDA removed tirzepatide from the drug shortage list, effectively ending legal compounding of the molecule in many jurisdictions

Chearwae et al