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Within 48 hours after injection of 100 or 1,000 mcg of Vitamin B12, 50 to 98% of the injected dose may appear in the urine

In the case of Apert syndrome, for example, there is good reason to believe that the causative mutation (in this case, predominantly a 755C-G transversion in the FGFR-2 gene) arises in spermatogonia and is selectively retained in the germinal epithelium because the mutant germ cells enjoy an unspecified selective advantage [4]