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Non-phosphorylated 4E-BP1 binds tightly to eukaryotic translation initiation factor 4E (eIF4E), a subunit of the eukaryotic initiation factor 4F complex responsible for mRNA cap binding, thereby inhibiting eIF4E-mediated initiation of protein synthesis (85)
Comorbid diabetic gastroparesis, particularly in the context of autonomic neuropathy, markedly amplifies the risk, tripling the odds of significant residual gastric content when compared with euglycemic individuals [32]
Follow-up monitoring and dose escalation schedule
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