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Some remarkable results are the decline of PSA after combination of metformin with bicalutamide after 8 weeks (42.1% bicalutamide + metformin vs 11.1% only bicalutamide) in PC patients with overweight (ClinicalTrial.gov ID NCT02614859), and with castration after 7 months (placebo PSA 58.2 ng/mL vs metformin PSA 8.36 ng/mL, ClinicalTrial.gov ID NCT01620593, [191]), and its detection in the prostatic tissue after consumption for 12 weeks, but without changes in tumor progression markers (ClinicalTrials.gov ID NCT01433913, [192])

TDC has received fees from Astra Zeneca for educational lectures that are outside the scope of this work

Specifically, FSFI-D scores increased by 0.30 in study 301 and 0.42 in study 302, and the FSDS-DAO scores decreased by 0.37 and 0.29, respectively