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5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

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The most important factor is consistency of timing and route day to day, since the mechanism works cumulatively rather than as an acute event to time around a meal

Studies suggest that Contrave involves pathways within the CNS, particularly regarding the hypothalamus