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The target maintenance doses are 2.4mg of each peptide gave once weekly on the same day

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12 Inflammation is likely to last for one to two weeks after treatment has finished

In addition, our previous studies revealed that microglia and their purinergic receptors (P2 4R, P2 7R and P2Y12R) were significantly upregulated in the TNC after NTG injection, and inhibiting microglial activation, including morphological and inflammatory changes, might affect neuronal hyperexcitability in the TNC, which ultimately relieved CM-associated allodynia [17,18,19]

Additionally, the 2 year trial provided not only robust data on semaglutide efficacy, but also safety