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However, high levels of 5-HT for a long period may lead to elevated osteoclast activity and bone resorption, which in turn result in osteoporosis

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In contrast, the rd10 mouse models genetically-induced rod death that progressively leads to cone death, as in RP, though the model is highly aggressive and the photoreceptor degeneration is very rapid and difficult to treat

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Multiple supplements have documented 5-AR inhibitory activity: Zinc High-dose zinc inhibits 5-alpha reductase in human skin fibroblasts (Stamatiadis et al., 1988)