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The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

Cochrane Database Syst Rev 2003;(3):CD004326

The results were highly illuminating

2 Vitamin B12 plays several important roles in the body, including: 3 Helping to produce energy by converting food into glucose Maintaining healthy nerve function Making DNA, the genetic material in all cells Helping to form red blood cells Helping enzymes to function as a cofactor Controlling homocysteine levels Vitamin B12 deficiency can lead to several health problems, including anemia, nerve damage, and neurologic symptoms such as memory loss and difficulty concentrating