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Furthermore, increased oxidative DNA damage, renal apoptosis, and organ dysfunction have been reported
Oxidized LDL cholesterol contributes to the development of atherosclerosis, which inhibits normal circulation of oxygenated blood to the tissues
Hepatic histopathology (Fig.4-A, B) showed that both semaglutide and tirzepatide significantly reduced the non-alcoholic fatty liver disease activity score (NAS) by decreasing steatosis and cell ballooning, compared to the non-restricted diet model group
The iron poisoning process is primarily mediated by the accumulation of lethal ROS and lipid peroxidation products and is significantly affected by iron metabolism (14)
Furthermore, most available studies are of short duration and lack long-term follow-up to assess whether repeated or chronic IF leads to sustained alterations in thyroid function or clinically meaningful hypothyroidism [60] (Table 2)
