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Pseudo-hierarchical erosion captures the structured depletion or destabilization of high-function reserve states defined by multi-dimensional stem cell fitness, including quiescence stability, self-renewal capacity, stress resilience, and activation competence and the downstream consequences for regenerative potential

Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, et al

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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

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