Red or purple chromaturia is a side effect of hydroxocobalamin, typically resolving over several weeks.2 Additional causes of red urine include blood (e.g., traumatic catheterization, malignancy, infection), dietary ingestion (e.g., beets), and medications (e.g., rifampin, phenothiazines).3 Although benign and not warranting further evaluation by itself, hydroxocobalamin-induced discolouration of body fluids may interfere with colorimetric sensors
290 , C852C861 (2006)
Since B12 is water-soluble, excess amounts are excreted through urine rather than stored in the body, reducing the risk of toxicity
Understanding the evidence, safety considerations, and lack of proven synergistic benefit is essential for informed clinical decision-making when patients consider combining these treatments
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