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Figure 4 5.1 Hypothesis and its limitations Moreover, elevated levels of non-esterified fatty acids (NEFAs) in follicles can contribute to lipid toxicity, potentially leading to oxidative stress, mitochondrial dysfunction, and cellular damage, adversely affecting follicle and oocyte health ( in vitro fertilization (IVF) outcomes ( 5.2 Unlocking statistical power for IVF outcome assessment with PSM, self-control via skewed analysis Randomized treatment assignment achieved balance in both known and unknown confounding factors between treatment groups
The medication is particularly effective when combined with basal insulin
At 3 months, mean body weight decreased by approximately 9%, accompanied by marked reductions in fat mass and visceral adipose tissue
Newer systematic reviews and meta-analyses suggest a slight increase in pancreatitis overall, although this may not be significant once background medications are considered, and no clear increase in pancreatic cancer has been consistently shown