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NASH: a mitochondrial disease

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True B12 toxicity symptoms are rare but may include skin reactions such as acne-like eruptions, mild gastrointestinal disturbances, and occasional headaches, particularly following injections

Dixon first discovered and named ferroptosis, the critical role of GPX4 in the inhibition of ferroptosis in his study has received widespread attention, mainly in the antioxidant axis system x c - -GSH-GPX4 ( c - is inhibited, obstruction of the cystine transport pathway can decrease GSH and GPX4, which can lead to cell death due to ongoing oxidative stress ( Figure 1A )