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Long-Term Safety Concerns: While short-term data are promising, the long-term impact of GLP-1, dual, and triple agonists on adolescent metabolic health remains unclear

Robles-Espinoza CD, Harland M, Ramsay AJ, Aoude LG, Quesada V, Ding Z et al

How Delayed Gastric Emptying Alters Drug Absorption Delayed gastric emptying is not a new concept, yet its clinical implications are becoming more relevant with GLP-1 therapies

While SLU-PP-332 mimics certain metabolic adaptations of exercise, it does not replace all benefits of physical activity, such as mechanical stress on bones and muscles, neuromuscular coordination, or psychological benefits

The ATTAIN-2 results reinforce the potential for orforglipron, as a once-daily oral, to deliver meaningful weight loss and A1C reduction, consistent with similar landmark trials for injectable GLP-1s, Custer added