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ROS are known to perform essential roles in controlling various biological events in plants, such as growth and development, stress tolerance, programmed cell death (PCD), etc

Specifically, low linear energy transfer (LET) IRs, including -rays and X-rays, induce the excitation and ionization of water molecules, leading to the production of ROS (mainly free radicals)

The skin needs time to complete its collagen remodeling cycle

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These characteristics have driven innovative covalent-targeting strategies in fragment-based drug discovery 16,17,18 , computer-based analysis of druggable targets 19,20 , and possible therapeutic applications 12,21,22,23,24