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Hillenburg decided to focus on a single main character: a sea sponge, the "weirdest" sea creature he could think of

Campbell-Walsh Urology

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In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

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