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A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

[8] [9] This sympathetic activation may be mediated through central nervous system pathways, as GLP-1 receptors are present in the hypothalamus and brainstem regions that regulate cardiovascular function

While generally well-tolerated, tirzepatide at higher doses may cause gastrointestinal symptoms, including nausea, diarrhea, constipation, and decreased appetite

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