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Patients should never discontinue or adjust doses of either medication without consulting their healthcare provider, as abrupt changes could adversely affect metabolic control

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However, beyond the efficacy for metabolic control, the current guidelines of diabetes mellitus pharmacotherapy are directed towards protection in the cardiovascular health and other complications, for which this pharmacological group is positioned as an important option, demonstrating a reduction of cardiovascular events compared to placebo which may be comparable to recent result from SGLT-2 inhibitors