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The observed upregulation of GSH, GST, and catalase, along with the reduced levels of LPO in the treated models, supports the hypothesis that antioxidants can attenuate the sensation of itch by reducing oxidative stress

Injections are usually given in the form of Hydroxocobalamin, a synthetic version of B12

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Variants like C677T and A1298C can reduce enzyme efficiency, potentially leading to higher homocysteine levels and impacting processes like detoxification, neurotransmitter production, and cardiovascular health

Again, the dose in compounded formulations is small, and whether it meaningfully affects glutathione status remains speculative