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7.2 Current management approaches: to optimize drug delivery systems Despite the promising pharmacologic effects of artemisinin and its derivatives, their clinical applications are limited due to their poor aqueous solubility, short half-life in blood circulation, low bioavailability, and poor stability (Qian et al., 2021)

doi: 10.3390/biology9060126 141 GiraudASMenheniottTRJuddLM

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526, 51 (2018).CrossRefGoogle ScholarPubMed Nakamura, M., Awaad, A., Hayashi, K., Ochiai, K., and Ishimura, K.: Thiol-organosilica particles internally functionalized with propidium iodide as a multicolor fluorescence and X-ray computed tomography probe and application for non-invasive functional gastrointestinal tract imaging