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Joint discomfort associated with B12 supplementation is uncommon and not listed amongst the recognised adverse effects in the Summary of Product Characteristics (SmPC) for licensed B12 preparations or in the British National Formulary (BNF)

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 35% by weight of the viscosity modulating agent(s)

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These variants can inform whether GLP-1 therapy aligns with your biology and may suggest which formulations or dosing strategies warrant discussion with your provider