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In its injectable form, Benadryl has a rapid onset of action

It can be used by adults with a body mass index (BMI) greater than or equal to 30 mg/kg alone or 27 mg/kg with at least one weight-related condition (e.g., high blood pressure, high cholesterol, Type 2 diabetes)

This is crucial to understand as eating too few calories can trigger 'metabolic adaptation' - where your body adapts to lack of fuel by burning fewer calories

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Tanaka S, Tanaka S, Iimuro S, Yamashita H, Katayama S, Akanuma Y, Yamada N, Araki A, Ito H, Sone H, Ohashi Y, Japan Diabetes Complications Study Group