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402 CBP/p300 Using the ovarian cancer cell line SKOV3, it has been reported that Staphylococcal nuclease domain-containing protein 1 (SND1) regulates the gene transcriptional activation of SLUG (an epithelial-to-mesenchymal transition marker) by increasing chromatin accessibility through the recruitment of the acetyltransferases GCN5 and CBP/p300 to the SLUG promoter proximal region

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TB-500 Proposed use : wound healing Outcome : Yes Margin : 8-6 in favor, with one abstention What the FDA was saying : There is not enough evidence of effectiveness for the proposed use

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