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Blood test markers to discuss with a clinician Marker IGF-1 Why it matters Tesamorelin increases IGF-1, so this marker helps track downstream GH-axis exposure

Upon activation by GLP-1RAs, GLP-1R initiates diverse intracellular cascades, such as the cyclic adenosine monophosphate (cAMP) / protein kinase A (PKA) pathway and phosphatidylinositol 3-kinase (PI3K) / protein kinase B (Akt) signaling pathway [1, 9]

Clinical Safety and Reproductive Considerations Pregnancy and Conception GLP-1 RAs are not recommended during pregnancy due to insufficient safety data

(ii) FDAs position that retatrutide and cagrilintide may not be used in compounding