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This must be a randomized, double-blind, placebo-controlled trial with a longer-term follow-up and large sample size, to evaluate efficacy, reliability and safety of skin-lightening effect of glutathione administered by the orobuccal route

From this data we conclude that MBTH-based kinetic experiments are a good alternative to the kinetic determinations described so far

Lancet 396 , 819829 (2020)

This adds another layer of complexity to dosage calculations, because timing, potential interactions, and total injection volume all need consideration

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