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Therefore, the use of such drugs should be limited to short-term therapeutic interventions, and whether the side effects associated with long-term use are manageable must be carefully evaluated

It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria

The best results are achieved by those willing to pair medication with long-term lifestyle changes

mBio 15 (11), e0231024

Huang et al., 2001