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This prolonged retention might increase intragastric pressure and potentially promote retrograde movement of gastric contents into the esophagus, particularly in patients with pre-existing lower esophageal sphincter dysfunction or hiatal hernia

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However, the research suggests some key distinctions: 1

However, this marked decrease in endogenous peripheral ghrelin levels did not prevent the GHSR antagonists JMV2959 and PF-5190457 from reducing binge-like alcohol drinking