Unlike older weight loss medications that only target one pathway, tirzepatide mimics two different hormones in the body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
Furthermore, we found that even in one-year follow up, GLP-1 can reduce the risk of osteoporosis and the HR is lower with the longer duration of follow up, which means GLP-1 RAs might have a lasting influence on bone metabolism
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December 23, 2019
References Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., Lau, D