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Some symptoms of dopamine depletion include: Lethargy Lack of energy Low motivation and drive Drop in libido Low pleasure response Easily gets discouraged Feelings of depression What can also happen is that if adrenaline stays connected to the adrenal receptors for too long and too strongly, the body can adjust by decreasing the sensitivity of the adrenal receptors, making you a lot less responsive to adrenaline, giving you the following symptoms: Hard to get motivated Lower muscle tone and strength Low self-confidence Low energy Hard to get a physical reaction Less desire to make social contacts Slower thinking Feelings of depression As you can see, in both cases we have symptoms of what we call CNS fatigue, which is simply a neurotransmitter issue