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Dual activation of mc3r and mc4r drives weight loss and reduces food intake in obese primates

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In conclusion, most animal studies support a beneficial effect of GLP-1RAs on NAFLD histology, including steatosis and inflammation, but not on fibrosis, while a few initial animal studies with GLP-1RA related polypeptides have provided limited evidence for a more favorable effect of peptide polyagonists on hepatic fibrosis