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In the study of triple-negative breast cancer (TNBC), researchers found that hybridized BLG@TPGS NPs were prepared by doping the multipath energy inhibitors berberine (BBR) and lonidamine (LND) as well as the chemotherapeutic agent garcinia cambogia (GA), which inherited the mitochondria-targeting ability of BBR and accurately accumulated in the mitochondria, then induced starvation therapy, which effectively eradicated cancer cells by coordinating the shutdown of tumor cells through the three-tendency strategy to cut off the mitochondrial respiration, glycolysis and glutamine metabolism [223]

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