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Early research on the mechanism was focused on TJ modulation, but subsequent studies put weight on membrane perturbation according to the surfactant structure of C10

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Subjects were monitored at baseline, at 1 month, and after 23 months of continuous daily supplemental l-carnitine ingestion by examination of the rate of plasma appearance of both d 3 -TMAO (Figure 4A) and d 3 -BB (Figure 4C) following oral d 3 -l-carnitine challenge

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