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Track weight and appetite for several weeks before making a judgement
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Both medications are currently listed on the FDA's drug shortages list , and again, when drugs are in shortage, compounding pharmacies are sometimes permitted to make their own versions by combining ingredients, provided they meet certain federal requirements
Sources Retatrutide discovery paper (Cell Metabolism) Cell Metabolism Phase 1b PK study (Lancet) The Lancet Metoprolol drug-interaction study ClinicalTrials.gov Related reading Retatrutide Dosage & Dosing Guide: Titration, Missed Doses, Taper Phase 3 titration schedule (246912 mg), missed-dose protocol, taper guidance, and dose-by-dose weight loss data
Dandona P, Chaudhuri A, Ghanim H
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