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[6] [7] This suggests there is no established direct causal relationship between semaglutide and joint pain based on controlled clinical trial data

While neither liraglutide nor semaglutide is FDA-approved for cardiovascular protection, research suggests both may help lower the risk of major heart-related events like heart attack, stroke, or cardiovascular death in people with type 2 diabetes

Top-line outcomes: STEP 4 maintenance data is particularly relevant for researchers modelling discontinuation effects: participants who stopped Semaglutide regained approximately two-thirds of lost weight within 1 year, while those continuing maintained their loss, supporting the hypothesis that chronic GLP-1R engagement is required for sustained metabolic effects

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11.1% on placebo) Headache: approximately 14% Fatigue: approximately 11% Dizziness: approximately 8% Hair thinning: approximately 3% (vs