Funding This study was funded by the High Level Chinese Medical Hospital Promotion Project (HLCMHPP2023089), the Special Programme for the Cultivation of Outstanding Young Scientific and Technological Talents (Innovation Category) under the Basic Scientific Research Fund of China Academy of Chinese Medical Sciences (ZZ13-YQ-019), and the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ-YQ2023004)
Identification of the exact mechanism for the lethal effect of silencing the enzyme requires further experiments, as do the effects of inhibitors, which are not necessarily solely due to loss of enzyme activity, because the inhibited enzyme may also have a gain of function leading to cell death [72]
The total weekly dose remains identical, but the peaks and troughs of drug concentration are smaller
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