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B12 is crucial for maintaining healthy nerve cells, producing DNA and RNA, and forming red blood cells

In the primary healthcare setting, the most commonly seen causes of vitamin B12 deficiency are related to abnormalities of digestion (atrophic gastritis, achlorhydria or the consequences of gastrectomy) or absorption (autoimmune pernicious anaemia, chronic pancreatitis, Crohns disease, the effect of medications that alter the mucosa of the ileum, or the consequences of surgical resection), and, to a lesser extent, a lack of exogenous supply

Variable composition, not molecularly standardised

Resolution metabolomes activated by hypoxic environment

Others may benefit from careful increases