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Methods: We included two studies Semaglutide Treatment Effect in People with obesity (STEP) 9, a randomized controlled trial, and the Shanghai Osteoarthritis Cohort (SOC), a large observational cohort reporting outcomes in body weight and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) domains

Feng P, Zhao H, Chai J, Huang L, Wang H

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The ALAD protein, which is a known target for TRXs and NTRC, was used as a positive control ( Figures 5B, C )

Its part of a group of drugs known as GLP-1 receptor agonists, which mimic hormones your body naturally produces to help with digestion and insulin release