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Lawsuits allege that some doctors encouraged off-label use of these medications for weight loss patients without providing adequate warnings about possible side effects like delayed gastric emptying, severe gastroparesis, and sudden vision loss

Periasamy S, Hsu DZ, Fu YH, & Liu MY

In particular, due to its amphiphilic characteristics, melatonin can diffuse and easily cross all morpho-physiological barriers, such as the placenta or the bloodbrain barrier 8,9 , and it can enter all cells of the body, influencing the function of a variety of tissues 10

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They work through several channels at once