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Patients already taking aspirin for cardiovascular prevention are doubling salicylate load, which increases bleeding risk and can contribute to salicylate toxicity at higher combined doses

The subsequent increase in nitric oxide (NO) production is a critical mediator of vasodilation and vascular permeability, processes essential for tissue repair

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These are usually most noticeable early on in treatment or after dose increases and tend to improve as the body adapts to the medication

Last month, Cigna became the latest organization to cease access for its employees