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The repeated application of topical steroids can lead to a decrease in the drugs effectiveness due to tachyphylaxis

Rhodes ([b]LER[/b] one of the dermatologists who authored the BMJs report) actually works with Clinuvel the company developing melanotan one for EPP, PMLE, AK, PDT, etc

However, BRAF-V600E mutation may lead to the upregulation of key genes involved in the innate immune response and may be associated with higher levels of immune-suppressive molecules (57)